Base Map

Hamster sera shown as open triangles. BA.1 reactivity increased by x2.4, JN.1 reactivity reduced by x0.2, Gamma reactivity reduced by x0.5.

Landscape titer (multi exposure) reactivities were adjusted by the same amount. Titers below the Limit of Detection (<LOD) titers were dealt with as LOD/2. The limit of detection for <LOD titers was adjusted by the same amount.

Landscapes for reduced map

GMT landscapes

No event

infection

XBB.1.5 boost

Infection + XBB.1.5 Boost

Individual landscapes

No event first

No event second

Infection first

Infection second

XBB.1.5 boost first

XBB.1.5 boost second

XBB.1.5 + Infection first

XBB.1.5 + Infection second

Landscape slopes

Landscape slopes quantify cross neutralization

##      infection first     infection second       no event first 
##            0.8698137            0.4278490            0.8970693 
##      no event second  vaccine + inf first vaccine + inf second 
##            0.8931188            0.9488968            0.5294982 
##        vaccine first       vaccine second 
##            0.8147309            0.6757184

Landscape residuals

Difference between fitted and measured data (calculated GMT).

Fitted and calculated GMT

Residuals

RMSE (root mean squared error) between individual sample titers and individual landscape fits. Difference is given as a factor as it is the difference of log2 titers.

Difference between adjusted and unadjusted residuals